Opportunity Information: Apply for W81XWH 19 TSCRP EHDA
The DoD Tuberous Sclerosis Complex (TSC) Exploration - Hypothesis Development Award is a U.S. Department of Defense research funding opportunity designed to help investigators test new, unconventional ideas in the TSC field at an early stage. Its central purpose is to enable the first serious exploration of innovative, high-risk, high-gain concepts that could reshape understanding of TSC biology, improve diagnosis, or point toward new therapeutic directions. Rather than funding large, mature programs, this mechanism is aimed at projects that are still at the "prove it" phase, where a compelling idea needs focused support to generate the preliminary results required to justify larger follow-on studies.
Projects proposed under this award are expected to be hypothesis-driven. Applicants need to present a clearly stated, testable hypothesis and back it with a strong scientific rationale and a study design that is appropriate for early-stage discovery work. The emphasis is on generating credible preliminary data that can open up new avenues of investigation, de-risk a novel research direction, or provide foundational evidence for future funding applications. In practical terms, the program favors bold concepts with the potential for major payoff, while still requiring careful planning and logical experimental structure.
The opportunity is administered by the Department of Defense, specifically the Department of the Army through the U.S. Army Medical Research Acquisition Activity (USAMRAA). It falls under the broader category of science and technology and other research and development and uses assistance instruments that may include grants and cooperative agreements. The listing is associated with CFDA number 12.420.
Eligibility is described as unrestricted, meaning it is open to a wide range of applicant organizations and entity types, as long as they meet any additional eligibility details that may be provided in the full announcement. The posting indicates an expectation of about five awards. The original posting dates show it was created on February 19, 2019, with an original closing date of May 9, 2019. The award ceiling is listed as 0 in the provided data, which typically signals that the maximum award amount may be defined elsewhere in the full solicitation materials or depends on programmatic constraints not captured in the summary record.
Overall, this award is best understood as seed funding for TSC research: it is meant to move a promising but not-yet-fully-validated idea from concept to initial evidence, positioning the work for more extensive investigation and future support.Apply for W81XWH 19 TSCRP EHDA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Tuberous Sclerosis Complex, Exploration- Hypothesis Development Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Feb 19, 2019.
- Applicants must submit their applications by May 09, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: DoD Tuberous Sclerosis Complex (TSC) Exploration - Hypothesis Development Award
What is the DoD Tuberous Sclerosis Complex (TSC) Exploration - Hypothesis Development Award?
It is a U.S. Department of Defense research funding opportunity intended to support early-stage, hypothesis-driven exploration of new and unconventional ideas in the tuberous sclerosis complex (TSC) field.
What is the main purpose of this award?
The central goal is to enable the first serious exploration of innovative, high-risk, high-gain concepts that could reshape understanding of TSC biology, improve diagnosis, or point toward new therapeutic directions.
What kind of research is this award designed to fund?
This mechanism is aimed at projects in a "prove it" phase where a compelling idea needs focused support to generate preliminary results that can justify larger follow-on studies.
Is the research required to be hypothesis-driven?
Yes. Projects proposed under this award are expected to be hypothesis-driven, with a clearly stated and testable hypothesis.
What should an application include at a high level?
Based on the summary provided, applicants should present a clear, testable hypothesis, a strong scientific rationale supporting that hypothesis, and a study design appropriate for early-stage discovery work.
What does "high-risk, high-gain" mean in the context of this award?
The program favors bold concepts with potential for major payoff, while still requiring careful planning and logical experimental structure to generate credible early evidence.
Is this award intended to fund large, mature research programs?
No. The award is specifically described as not funding large, mature programs. It is intended as seed funding to move promising ideas from concept to initial evidence.
What outcomes is the program trying to achieve?
The emphasis is on generating credible preliminary data that can open new avenues of investigation, de-risk a novel research direction, or provide foundational evidence for future funding applications.
Who administers this funding opportunity?
The opportunity is administered by the Department of Defense, specifically the Department of the Army through the U.S. Army Medical Research Acquisition Activity (USAMRAA).
What general funding category does this opportunity fall under?
It falls under the broader category of science and technology and other research and development.
What funding instruments may be used for awards under this opportunity?
The summary indicates the assistance instruments may include grants and cooperative agreements.
What is the CFDA number associated with this opportunity?
The listing is associated with CFDA number 12.420.
Who is eligible to apply?
Eligibility is described as unrestricted, meaning it is open to a wide range of applicant organizations and entity types, subject to any additional eligibility details provided in the full announcement.
How many awards are expected to be made?
The posting indicates an expectation of about five awards.
When was the opportunity posted and when did it close (based on the posting information provided)?
The original posting dates show it was created on February 19, 2019, with an original closing date of May 9, 2019.
What is the maximum (ceiling) award amount?
The award ceiling is listed as 0 in the provided data. This typically suggests the maximum award amount may be defined elsewhere in the full solicitation materials or may depend on programmatic constraints not captured in the summary record.
Does the summary specify a minimum award amount or a typical award size?
No specific minimum, typical, or maximum award size is provided in the summary beyond the note that the ceiling is listed as 0 and may be defined in the full announcement.
What types of TSC impacts does the award aim to support?
The award is positioned to support work that could reshape understanding of TSC biology, improve diagnosis, or point toward new therapeutic directions.
How should this award be understood in practical terms?
It is best understood as seed funding for TSC research intended to generate initial evidence that positions a new idea for more extensive investigation and future support.
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| FY 2020 DEFENSE UNIVERSITY RESEARCH INSTRUMENTATION PROGRAM (DURIP) Apply for N00014 19 S F007 Funding Number: N00014 19 S F007 Agency: Department of Defense, Office of Naval Research Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Cooperative Ecosystem Studies Unit, Colorado Plateau CESU Apply for G19AS00029 Funding Number: G19AS00029 Agency: Department of the Interior, U. S. Geological Survey Category: Science and Technology and other Research and Development Funding Amount: $33,299 |
| Cooperative Ecosystem Studies Unit (CESU), Gulf Coast CESU Apply for G19AS00027 Funding Number: G19AS00027 Agency: Department of the Interior, U. S. Geological Survey Category: Science and Technology and other Research and Development Funding Amount: $137,599 |
| Cooperative Ecosystem Studies Unit, Californian CESU Apply for G19AS00032 Funding Number: G19AS00032 Agency: Department of the Interior, U. S. Geological Survey Category: Science and Technology and other Research and Development Funding Amount: $116,000 |
| High-Energy-Density Laboratory Plasma Science Apply for DE FOA 0002088 Funding Number: DE FOA 0002088 Agency: Department of Energy - Office of Science, Office of Science Category: Science and Technology and other Research and Development Funding Amount: $250,000 |
| DoD Ovarian Cancer Academy - Early Career Investigator Award Apply for W81XWH 19 OCRP OCA Funding Number: W81XWH 19 OCRP OCA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Ovarian Cancer Pilot Award Apply for W81XWH 19 OCRP PA Funding Number: W81XWH 19 OCRP PA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Ovarian Cancer Academy Dean and Assistant Dean (Leadership) Award Apply for W81XWH 19 OCRP OCADEAN Funding Number: W81XWH 19 OCRP OCADEAN Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Ovarian Cancer Investigator-Initiated Research Award Apply for W81XWH 19 OCRP IIRA Funding Number: W81XWH 19 OCRP IIRA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Announcement of the Availability of Funds for Conferences on Research Integrity Apply for IR ORI 19 002 Funding Number: IR ORI 19 002 Agency: Department of Health and Human Services, Office of the Assistant Secretary for Health Category: Science and Technology and other Research and Development Funding Amount: $50,000 |
| Department of Defense Advanced Computing Initiative (ACI) Fiscal Year 2019 Apply for W911NF 19 S 0007 Funding Number: W911NF 19 S 0007 Agency: Department of Defense, Dept of the Army -- Materiel Command Category: Science and Technology and other Research and Development Funding Amount: $2,000,000 |
| Cooperative Ecosystem Studies Unit, Southern Appalachian CESU Apply for G19AS00028 Funding Number: G19AS00028 Agency: Department of the Interior, U. S. Geological Survey Category: Science and Technology and other Research and Development Funding Amount: $45,000 |
| Cooperative Ecosystem Studies Unit, Great Lakes Northern Forests CESU Apply for G19AS00030 Funding Number: G19AS00030 Agency: Department of the Interior, U. S. Geological Survey Category: Science and Technology and other Research and Development Funding Amount: $48,057 |
| Cultural Anthropology Program - Doctoral Dissertation Research Improvement Grants Apply for 19 560 Funding Number: 19 560 Agency: National Science Foundation Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Geoinformatics Apply for 19 561 Funding Number: 19 561 Agency: National Science Foundation Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Planning Grants for Engineering Research Centers (ERC) Apply for 19 562 Funding Number: 19 562 Agency: National Science Foundation Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Ovarian Cancer Clinical Development Award Apply for W81XWH 19 OCRP CDA Funding Number: W81XWH 19 OCRP CDA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD Military Burn - Idea Development Award Apply for W81XWH 19 MBRP IDA Funding Number: W81XWH 19 MBRP IDA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD Military Burn - Clinical Translation Research Award Apply for W81XWH 19 MBRP CTRA Funding Number: W81XWH 19 MBRP CTRA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Cooperative Ecosystem Studies Unit (CESU), Californian CESU Apply for G19AS00035 Funding Number: G19AS00035 Agency: Department of the Interior, U. S. Geological Survey Category: Science and Technology and other Research and Development Funding Amount: $49,000 |
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