Powering Research through Innovative Methods for mixtures in Epidemiology (PRIME) (R01) | RFA ES 17 001

Opportunity Information: Apply for RFA ES 17 001

Powering Research through Innovative Methods for mixtures in Epidemiology (PRIME) (R01) is a National Institutes of Health (NIH) grant opportunity designed to push forward new and better quantitative ways to study how real-world exposures to multiple chemicals affect human health. Instead of focusing on one chemical at a time, the FOA centers on complex chemical mixtures, which is how exposures typically occur in homes, workplaces, consumer products, food, water, and air. The main goal is to stimulate development of innovative statistical methods, data science techniques, and other quantitative approaches that can strengthen environmental epidemiology research on mixtures by improving how researchers model, interpret, and draw conclusions about combined exposures and their health impacts.

This opportunity is issued as a discretionary grant under the R01 activity code, which generally supports well-developed, investigator-initiated research projects. It falls under the Environment and Health funding activity category and is associated with CFDA number 93.113. The funding opportunity number is RFA-ES-17-001, and it was created on October 19, 2016, with an original application closing date of February 22, 2017. The listed award ceiling is $350,000, indicating the maximum award amount expected per award under the announcement, as presented in the source data.

A key feature of the FOA is its broad eligibility. In addition to standard applicants such as public and private institutions of higher education, nonprofits, and government entities, the announcement explicitly encourages participation from a wide range of organizations and communities. Eligible applicants include state, county, city/township, and special district governments; independent school districts; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; and Native American tribal organizations that are not federally recognized tribal governments. The eligibility list also includes nonprofits both with and without 501(c)(3) status, for-profit organizations (other than small businesses), and small businesses. Beyond these typical categories, the FOA highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions; Asian American, Native American, and Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; regional organizations; U.S. territories or possessions; tribal governments that are not federally recognized; and even non-U.S. entities (foreign organizations). This breadth suggests an intent to draw in diverse expertise, datasets, perspectives, and community connections that can improve mixtures research.

In practical terms, PRIME (R01) is aimed at methodological innovation: developing, refining, and validating tools that help researchers understand mixture effects more accurately and credibly. While the source text does not list specific required topics, the stated emphasis on "innovative statistical, data science, or other quantitative approaches" signals interest in advances that could address common challenges in mixtures epidemiology, such as highly correlated exposures, interactions among chemicals, non-linear dose-response patterns, varying susceptibility across populations, measurement error, missing data, high-dimensional exposure metrics, time-varying exposures, and difficulties translating complex model results into interpretable public health conclusions. The overall focus is on strengthening the scientific foundation for evaluating combined chemical exposures in human populations, with the end result being more reliable evidence to inform environmental health understanding and, ultimately, prevention and policy.

• The National Institutes of Health in the environment, health sector is offering a public funding opportunity titled "Powering Research through Innovative Methods for mixtures in Epidemiology (PRIME) (R01)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113.
• This funding opportunity was created on 2016-10-19.
• Applicants must submit their applications by 2017-02-22. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $350,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA ES 17 001

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