Opportunity Information: Apply for RFA ES 17 001
Powering Research through Innovative Methods for mixtures in Epidemiology (PRIME) (R01) is a National Institutes of Health (NIH) grant opportunity designed to push forward new and better quantitative ways to study how real-world exposures to multiple chemicals affect human health. Instead of focusing on one chemical at a time, the FOA centers on complex chemical mixtures, which is how exposures typically occur in homes, workplaces, consumer products, food, water, and air. The main goal is to stimulate development of innovative statistical methods, data science techniques, and other quantitative approaches that can strengthen environmental epidemiology research on mixtures by improving how researchers model, interpret, and draw conclusions about combined exposures and their health impacts.
This opportunity is issued as a discretionary grant under the R01 activity code, which generally supports well-developed, investigator-initiated research projects. It falls under the Environment and Health funding activity category and is associated with CFDA number 93.113. The funding opportunity number is RFA-ES-17-001, and it was created on October 19, 2016, with an original application closing date of February 22, 2017. The listed award ceiling is $350,000, indicating the maximum award amount expected per award under the announcement, as presented in the source data.
A key feature of the FOA is its broad eligibility. In addition to standard applicants such as public and private institutions of higher education, nonprofits, and government entities, the announcement explicitly encourages participation from a wide range of organizations and communities. Eligible applicants include state, county, city/township, and special district governments; independent school districts; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; and Native American tribal organizations that are not federally recognized tribal governments. The eligibility list also includes nonprofits both with and without 501(c)(3) status, for-profit organizations (other than small businesses), and small businesses. Beyond these typical categories, the FOA highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions; Asian American, Native American, and Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; regional organizations; U.S. territories or possessions; tribal governments that are not federally recognized; and even non-U.S. entities (foreign organizations). This breadth suggests an intent to draw in diverse expertise, datasets, perspectives, and community connections that can improve mixtures research.
In practical terms, PRIME (R01) is aimed at methodological innovation: developing, refining, and validating tools that help researchers understand mixture effects more accurately and credibly. While the source text does not list specific required topics, the stated emphasis on "innovative statistical, data science, or other quantitative approaches" signals interest in advances that could address common challenges in mixtures epidemiology, such as highly correlated exposures, interactions among chemicals, non-linear dose-response patterns, varying susceptibility across populations, measurement error, missing data, high-dimensional exposure metrics, time-varying exposures, and difficulties translating complex model results into interpretable public health conclusions. The overall focus is on strengthening the scientific foundation for evaluating combined chemical exposures in human populations, with the end result being more reliable evidence to inform environmental health understanding and, ultimately, prevention and policy.Apply for RFA ES 17 001
- The National Institutes of Health in the environment, health sector is offering a public funding opportunity titled "Powering Research through Innovative Methods for mixtures in Epidemiology (PRIME) (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113.
- This funding opportunity was created on 2016-10-19.
- Applicants must submit their applications by 2017-02-22. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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PRIME (R01) Grant Opportunity (RFA-ES-17-001) - FAQs
What is the PRIME (R01) funding opportunity?
Powering Research through Innovative Methods for mixtures in Epidemiology (PRIME) (R01) is a National Institutes of Health (NIH) grant opportunity focused on advancing quantitative methods for studying how real-world exposure to multiple chemicals (chemical mixtures) affects human health.
What problem is this FOA trying to address?
Environmental exposures typically happen as mixtures (not one chemical at a time) through places like homes, workplaces, consumer products, food, water, and air. This opportunity aims to strengthen the methods researchers use to model, interpret, and draw conclusions about combined exposures and their health impacts.
What is the main goal of the PRIME (R01) announcement?
The main goal is to stimulate development of innovative statistical methods, data science techniques, and other quantitative approaches that improve environmental epidemiology research on mixtures, especially the credibility and interpretability of mixture-related health findings.
What type of grant mechanism is PRIME using?
This opportunity is issued as a discretionary grant under the NIH R01 activity code, which generally supports well-developed, investigator-initiated research projects.
What is the funding opportunity number?
The funding opportunity number is RFA-ES-17-001.
What funding category does this opportunity fall under?
It falls under the Environment and Health funding activity category.
What CFDA number is associated with this opportunity?
The associated CFDA number is 93.113.
When was this funding opportunity created?
The opportunity was created on October 19, 2016.
What was the original application closing date?
The original application closing date listed is February 22, 2017.
What is the award ceiling for this FOA?
The listed award ceiling is $350,000, representing the maximum award amount expected per award under the announcement (as presented in the source data).
Is PRIME focused on single chemicals or chemical mixtures?
PRIME is specifically centered on complex chemical mixtures, reflecting how exposures typically occur in real life rather than as isolated single-chemical exposures.
What kinds of approaches does PRIME want to support?
The FOA emphasizes innovative statistical methods, data science techniques, and other quantitative approaches aimed at improving how mixture effects are studied in human populations.
Does the FOA list specific required research topics?
No specific required topics are listed in the provided information. The emphasis is broadly on methodological innovation for mixtures epidemiology.
What methodological challenges in mixtures epidemiology is this FOA trying to improve?
Based on the stated emphasis on innovative quantitative approaches, the opportunity signals interest in methods that address common mixtures challenges such as highly correlated exposures, interactions among chemicals, non-linear dose-response patterns, differing susceptibility across populations, measurement error, missing data, high-dimensional exposure metrics, time-varying exposures, and difficulties translating complex model results into interpretable public health conclusions.
What kinds of settings and sources of exposure are relevant to PRIME?
The FOA frames relevant exposures as those occurring in everyday contexts, including homes, workplaces, consumer products, food, water, and air.
Who is eligible to apply?
Eligibility is broad. The announcement includes (and encourages participation from) a wide range of organizations across academia, government, nonprofit, private sector, and community-based groups, including foreign organizations.
Are institutions of higher education eligible?
Yes. Public and private institutions of higher education are included among eligible applicants.
Are nonprofits eligible, and do they need 501(c)(3) status?
Nonprofits are eligible both with and without 501(c)(3) status.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are listed as eligible, and small businesses are also listed as eligible.
Are small businesses eligible to apply?
Yes, small businesses are included in the eligibility list.
Are state and local governments eligible?
Yes. Eligible applicants include state governments, county governments, city/township governments, and special district governments.
Are school districts eligible?
Yes. Independent school districts are included among eligible applicants.
Are tribal governments eligible?
Yes. Federally recognized Native American tribal governments are eligible, and the eligibility list also includes tribal governments that are not federally recognized, as well as Native American tribal organizations that are not federally recognized tribal governments.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are listed among eligible applicants.
Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are included in the eligibility list.
Are federally eligible agencies included?
Yes. Eligible federal agencies are listed as eligible applicants.
Are community-based or faith-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly highlighted as eligible applicants.
Are minority-serving institutions specifically included?
Yes. The FOA highlights eligibility for Alaska Native and Native Hawaiian Serving Institutions; Asian American, Native American, and Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); and Tribally Controlled Colleges and Universities (TCCUs).
Are regional organizations eligible?
Yes. Regional organizations are included in the eligibility list.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. The eligibility list explicitly includes non-U.S. entities (foreign organizations).
What is the intended scientific or public health impact of PRIME-funded work?
The intent is to strengthen the scientific foundation for evaluating combined chemical exposures in human populations, producing more reliable evidence to inform environmental health understanding and ultimately support prevention and policy.
Is this opportunity mainly about developing new methods, or applying existing methods?
Based on the provided description, it is primarily aimed at methodological innovation: developing, refining, and validating tools that improve mixtures epidemiology.
What does the FOA suggest about the kind of expertise it wants to attract?
The broad eligibility and emphasis on innovative quantitative approaches suggest the FOA is trying to draw diverse expertise, datasets, perspectives, and community connections that can improve mixtures research.
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Applicants also applied for:
Applicants who have applied for this opportunity (RFA ES 17 001) also looked into and applied for these:
| Funding Opportunity |
|---|
| NIH Revision Awards for Creating Virtual Consortium for Translational/Transdisciplinary Environmental Research (ViCTER)(R01) Apply for RFA ES 17 002 Funding Number: RFA ES 17 002 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Summer Research Experiences for Students and Science Teachers (Admin Supp) Apply for PA 17 055 Funding Number: PA 17 055 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Centers for Oceans and Human Health 3: Impacts of Climate Change on Oceans and Great Lakes (COHH3) (P01) Apply for RFA ES 16 009 Funding Number: RFA ES 16 009 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $900,000 |
| Environmental influences on Placental Origins of Development (ePOD) (R01) Apply for RFA ES 17 005 Funding Number: RFA ES 17 005 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
| Environmental Health Sciences Core Centers (EHS CC) (P30) Apply for RFA ES 17 003 Funding Number: RFA ES 17 003 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| SBIR E-learning for HAZMAT and Emergency Response (R43/R44) Apply for RFA ES 17 004 Funding Number: RFA ES 17 004 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $100,000 |
| Exposure Analysis Services for the Environmental Influences on Child Health Outcomes (ECHO) Program (Admin Supp) Apply for PA 17 308 Funding Number: PA 17 308 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Global Brain and Nervous System Disorders Research Across the Lifespan (R21) Apply for PAR 17 313 Funding Number: PAR 17 313 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $125,000 |
| Global Brain and Nervous System Disorders Research Across the Lifespan (R01) Apply for PAR 17 314 Funding Number: PAR 17 314 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Novel Assays for Screening the Effects of Chemical Toxicants on Cell Differentiation (SBIR R44) Apply for RFA ES 17 007 Funding Number: RFA ES 17 007 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Organotypic Culture Models developed from Experimental Animals for Chemical Toxicity Screening (R43) Apply for RFA ES 17 008 Funding Number: RFA ES 17 008 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Population-Based Model Organism Research for G x E Exploration in Complex Disease Outcomes (R01 Clinical Trial Not Allowed) Apply for RFA ES 17 009 Funding Number: RFA ES 17 009 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $499,999 |
| Immuno-Oncology Translational Network (IOTN): Cancer Immunotherapy Research Projects (U01) Apply for RFA CA 17 045 Funding Number: RFA CA 17 045 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $500,000 |
| Outstanding New Environmental Scientist (ONES) Award (R01 Clinical Trial Optional) Apply for RFA ES 18 001 Funding Number: RFA ES 18 001 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Environmental Health Sciences Core Centers (EHS CC) (P30 Clinical Trial Optional) Apply for RFA ES 18 003 Funding Number: RFA ES 18 003 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Transition to Independent Environmental Health Research (TIEHR) Career Transition Award (K01 Clinical Trial Required) Apply for PAR 18 261 Funding Number: PAR 18 261 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Transition to Independent Environmental Health Research (TIEHR) Career Transition Award (K01 Clinical Trial Not Allowed) Apply for PAR 18 291 Funding Number: PAR 18 291 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| The Role of the Microbiome in the Developmental Origins of Health and Disease (DOHaD) (R01 Clinical Trial Not Allowed) Apply for RFA ES 18 005 Funding Number: RFA ES 18 005 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
| Revolutionizing Innovative, Visionary Environmental health Research (RIVER) (R35 Clinical Trial Not Allowed) Apply for RFA ES 18 004 Funding Number: RFA ES 18 004 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $600,000 |
| SBIR E-learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed) Apply for RFA ES 18 006 Funding Number: RFA ES 18 006 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $100,000 |
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