Opportunity Information: Apply for RFA HL 16 012
The Household Air Pollution (HAP) Health Outcomes Trial (UM1) funding opportunity (RFA-HL-16-012) is a National Institutes of Health cooperative agreement designed to support a large, multi-country clinical trial focused on reducing health harms from household air pollution. The core goal is to rigorously test whether improved cookstove and cleaner fuel interventions actually lead to measurable improvements in health outcomes among populations that are routinely exposed to smoke and other pollutants from traditional household cooking and heating practices. A defining feature of the program is its required scale and generalizability: the trial must be conducted across three or more Low and Middle Income Country (LMIC) settings, indicating NIH is looking for evidence that holds up across different cultural, geographic, and environmental contexts rather than results from a single site or country.
This award uses the UM1 mechanism, meaning it is a cooperative agreement rather than a standard research grant. In practice, that typically implies substantial scientific and programmatic involvement by NIH staff during the project, such as coordinated oversight, milestone-driven management, harmonization across sites, and closer collaboration on trial design, implementation, and data quality expectations. The work is framed as a clinical trial, so applicants are expected to propose a clear intervention, well-defined outcomes, and a rigorous evaluation plan that can credibly establish whether the stove and fuel improvements reduce harmful exposures and translate into better health.
In addition to the intervention trial itself, each application must include a biomarker center component. This requirement signals that the program is not only interested in endpoints like illness rates or physiological measures, but also in building stronger tools for measuring exposure and biological response. The biomarker center is expected to develop and validate markers that fall into categories such as clinical, physiological, chemical, biochemical, and/or microbiological indicators. These markers must cover (a) exposure biomarkers, which help quantify what people are actually inhaling or absorbing (for example, pollutant-related indicators that reflect smoke exposure), and (b) biomarkers of pathophysiological responses, which capture how the body is being affected (for example, indicators linked to inflammation, cardiopulmonary stress, or other biological pathways relevant to pollution-related disease). By making this a required element, NIH is pushing for stronger measurement science that can help interpret trial results, improve comparability across settings, and support future studies and public health programs.
Eligibility for applicants is broad across U.S.-based organization types, spanning state, county, city, and special district governments; public and state-controlled institutions of higher education; private institutions of higher education; independent school districts; Native American tribal governments (federally recognized); public housing authorities and Indian housing authorities; tribal organizations that are not federally recognized; nonprofits with or without 501(c)(3) status; for-profit organizations (other than small businesses); and small businesses. The FOA also explicitly highlights additional eligible applicant categories including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), faith-based or community-based organizations, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), regional organizations, eligible federal agencies, and U.S. territories or possessions. At the same time, it draws a clear boundary around foreign eligibility: non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply as the applicant organization. However, non-domestic components of U.S. organizations are eligible to participate, and foreign components (as defined in the NIH Grants Policy Statement) are allowed, which aligns with the requirement to conduct work in LMIC settings while keeping the primary applicant anchored in the United States.
Administratively, the opportunity is categorized as discretionary funding and uses a cooperative agreement as its funding instrument type. The activity category is listed broadly across areas including education, environment, health, income security, and social services, reflecting the cross-cutting nature of household energy and health. The FOA lists multiple CFDA numbers (93.113, 93.310, 93.393, 93.399, 93.838, 93.865, 93.989), consistent with NIH’s structure where multiple institutes, centers, or program areas can be involved. The original closing date was 2016-01-19, with an award ceiling of $5,075,000 and an expectation of one award, which suggests NIH intended to fund a single, large, coordinated effort rather than several smaller independent trials. The opportunity was created on 2015-10-02, positioning it as a time-limited call for a major, high-impact trial capable of producing definitive evidence on whether improved household stoves and fuels can reduce exposure and improve health, while simultaneously advancing biomarker development to strengthen how future household air pollution research is measured and interpreted.Apply for RFA HL 16 012
- The National Institutes of Health in the education, environment, health, income security and social services sector is offering a public funding opportunity titled "Household Air Pollution (HAP) Health Outcomes Trial (UM1)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.310, 93.393, 93.399, 93.838, 93.865, 93.989.
- This funding opportunity was created on 2015-10-02.
- Applicants must submit their applications by 2016-01-19. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $5,075,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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