Opportunity Information: Apply for RFA ES 16 004
The Environmental Health Cohorts Maintenance and Infrastructure (R24) funding opportunity (RFA-ES-16-004) is a discretionary NIH grant from the National Institute of Environmental Health Sciences (NIEHS) designed to keep established Environmental Epidemiology Cohorts (EECs) scientifically productive and ready for new research. Instead of primarily funding new hypothesis-driven studies, the core emphasis is on sustaining and strengthening the foundational “backbone” of existing cohorts: the staff, systems, and shared resources that allow cohorts to continue operating, retaining participants, maintaining data and biospecimens, and staying positioned to compete for and rapidly launch future research projects. A central theme is maximizing prior NIEHS investments by preventing cohort degradation over time and by making cohort resources more usable to a wider range of environmental health researchers.
The FOA supports two closely related aims. First, it funds maintenance of existing cohorts, meaning the ongoing work required to preserve cohort integrity and value, such as continued participant tracking and retention activities, upkeep of study documentation and protocols, management of data and specimen inventories, and routine operational functions that keep the cohort viable. Second, it funds enhancements to research infrastructure that improve scientific capabilities and facilitate broader resource sharing. This includes building or improving systems for data management, standardization, curation, and documentation; strengthening governance, access procedures, and collaboration mechanisms; and upgrading tools that make it easier for outside scientists to understand what the cohort contains and how to work with it. The overall expectation is that awardees will emerge with a more robust, collaborative, and “research-ready” cohort platform that can support future environmental epidemiology investigations and partnerships.
Eligibility is broad and includes many types of U.S.-based organizations and governmental units. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public housing authorities/Indian housing authorities; federally recognized Native American tribal governments; tribal organizations (other than federally recognized tribal governments); public and state-controlled and private institutions of higher education; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other organizations as permitted by NIH. The announcement also explicitly highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISISs, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions.
Foreign eligibility is limited in a specific way. Non-domestic (non-U.S.) entities, including foreign institutions, are not eligible to apply as the primary applicant, and non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components, as defined in the NIH Grants Policy Statement, are allowed, meaning the project can include certain foreign collaborators or elements if they meet NIH’s definition and requirements, even though the main applicant organization must be domestic.
Administratively, this opportunity falls under the Environment and Health activity area (CFDA 93.113) and uses the NIH R24 mechanism, which is typically intended for resource-related research projects and infrastructure support. The listed award ceiling is $250,000, and the original closing date for the opportunity was August 10, 2018 (with a creation date of August 1, 2016). Overall, the program is best understood as targeted support to protect and modernize existing environmental epidemiology cohorts so they can be sustained, shared, and leveraged more effectively for future NIEHS-aligned research and collaborative science.Apply for RFA ES 16 004
- The National Institutes of Health in the environment, health sector is offering a public funding opportunity titled "Environmental Health Cohorts Maintenance and Infrastructure (R24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113.
- This funding opportunity was created on 2016-08-01.
- Applicants must submit their applications by 2018-08-10. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the Environmental Health Cohorts Maintenance and Infrastructure (R24) funding opportunity?
It is a discretionary NIH grant funding opportunity from the National Institute of Environmental Health Sciences (NIEHS) intended to keep established Environmental Epidemiology Cohorts (EECs) scientifically productive and ready to support new research.
What is the FOA number and title referenced for this opportunity?
The opportunity is described as the Environmental Health Cohorts Maintenance and Infrastructure (R24), with FOA number RFA-ES-16-004.
Which NIH Institute sponsors this grant?
The sponsoring NIH Institute is the National Institute of Environmental Health Sciences (NIEHS).
What is the main purpose of this R24 compared with a typical research grant?
The main purpose is to sustain and strengthen the foundational "backbone" of existing cohorts (staff, systems, shared resources, and operational capacity) rather than primarily funding new hypothesis-driven studies.
What does NIEHS mean by maintaining an existing cohort?
Maintenance refers to the ongoing work needed to preserve cohort integrity and value, including participant tracking and retention, upkeep of study documentation and protocols, management of data and specimen inventories, and routine operational functions that keep the cohort viable.
What kinds of infrastructure enhancements does the FOA support?
The FOA supports enhancements that improve scientific capabilities and facilitate broader resource sharing, such as improved data management systems, standardization, curation and documentation, stronger governance and access procedures, and upgraded tools that help outside scientists understand cohort contents and how to work with the cohort.
What are the two closely related aims supported by this funding opportunity?
The two aims are: (1) maintenance of existing cohorts to preserve integrity and value, and (2) enhancements to research infrastructure to improve capability, collaboration, and sharing.
What is meant by keeping cohorts "research-ready"?
It means keeping the cohort operational and positioned to compete for and rapidly launch future research projects, supported by maintained operations and stronger infrastructure for data, biospecimens, documentation, and collaboration.
How does this program aim to maximize prior NIEHS investments?
It is designed to prevent cohort degradation over time by supporting continued maintenance and modernization, and by making cohort resources more usable to a wider range of environmental health researchers.
What types of projects or activities are emphasized as core "backbone" support?
Emphasized activities include sustaining staff and systems, retaining and tracking participants, maintaining data and biospecimens, managing documentation and protocols, and keeping shared resources functioning so the cohort remains viable.
Is the program intended to fund new hypothesis-driven studies as the primary focus?
No. The core emphasis is on sustaining and strengthening existing cohorts and their infrastructure, rather than primarily funding new hypothesis-driven research studies.
What is the grant mechanism used for this opportunity?
This opportunity uses the NIH R24 mechanism, which is typically intended for resource-related research projects and infrastructure support.
What activity area and CFDA number are associated with this opportunity?
It falls under the Environment and Health activity area and is associated with CFDA 93.113.
What is the maximum (ceiling) award amount listed for this opportunity?
The listed award ceiling is $250,000.
When was this funding opportunity created and when was it originally due?
The creation date is listed as August 1, 2016, and the original closing date is listed as August 10, 2018.
Who can apply for this grant (in general terms)?
Eligibility is broad and includes many types of U.S.-based organizations and governmental units, including government entities, higher education institutions, nonprofits, and for-profit organizations (including small businesses), as permitted by NIH.
Which U.S. government entities are eligible to apply?
Eligible government applicants include state, county, city/township, and special district governments, as well as independent school districts, public housing authorities/Indian housing authorities, federally recognized Native American tribal governments, and eligible federal agencies.
Are tribal organizations eligible to apply?
Yes. Eligible applicants include federally recognized Native American tribal governments and tribal organizations (other than federally recognized tribal governments).
Are colleges and universities eligible to apply?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are nonprofit organizations eligible to apply, including those without 501(c)(3) status?
Yes. The eligibility list includes nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education).
Are for-profit organizations eligible to apply?
Yes. Eligible applicants include for-profit organizations other than small businesses, and small businesses.
Are faith-based or community-based organizations included as eligible applicants?
Yes. The announcement explicitly highlights faith-based or community-based organizations among eligible applicant types.
Are minority-serving institutions specifically highlighted as eligible applicants?
Yes. The announcement highlights Alaska Native and Native Hawaiian Serving Institutions, AANAPISISs, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and related categories.
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are explicitly highlighted as eligible applicant types.
Can a non-U.S. (foreign) institution apply as the primary applicant?
No. Non-domestic (non-U.S.) entities, including foreign institutions, are not eligible to apply as the primary applicant.
Can a non-domestic component of a U.S. organization apply?
No. Non-domestic components of U.S. organizations are also not eligible to apply.
Are foreign collaborators allowed in any form?
Yes. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. This means a project may include certain foreign collaborators or elements if they meet NIH's definition and requirements, even though the main applicant must be domestic.
What is the overall expected outcome for awardees?
The expectation is that awardees will have a more robust, collaborative, and "research-ready" cohort platform that can support future environmental epidemiology investigations and partnerships.
How does this funding opportunity support broader use of cohort resources?
It supports improvements that make cohort resources easier to understand and access for a wider range of environmental health researchers, including better data systems, clearer documentation, standardized and curated resources, and strengthened governance and access procedures.
What is the program trying to prevent from happening to cohorts over time?
It aims to prevent cohort degradation over time by sustaining operations and modernizing infrastructure so the cohort remains valuable and usable.
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Applicants also applied for:
Applicants who have applied for this opportunity (RFA ES 16 004) also looked into and applied for these:
| Funding Opportunity |
|---|
| Novel Methods for Obtaining Molecular Information from Archived Tissue Samples (R43/R44) Apply for RFA ES 16 012 Funding Number: RFA ES 16 012 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Powering Research through Innovative Methods for mixtures in Epidemiology (PRIME) (R01) Apply for RFA ES 17 001 Funding Number: RFA ES 17 001 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $350,000 |
| NIH Revision Awards for Creating Virtual Consortium for Translational/Transdisciplinary Environmental Research (ViCTER)(R01) Apply for RFA ES 17 002 Funding Number: RFA ES 17 002 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Summer Research Experiences for Students and Science Teachers (Admin Supp) Apply for PA 17 055 Funding Number: PA 17 055 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Centers for Oceans and Human Health 3: Impacts of Climate Change on Oceans and Great Lakes (COHH3) (P01) Apply for RFA ES 16 009 Funding Number: RFA ES 16 009 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $900,000 |
| Environmental influences on Placental Origins of Development (ePOD) (R01) Apply for RFA ES 17 005 Funding Number: RFA ES 17 005 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
| Environmental Health Sciences Core Centers (EHS CC) (P30) Apply for RFA ES 17 003 Funding Number: RFA ES 17 003 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| SBIR E-learning for HAZMAT and Emergency Response (R43/R44) Apply for RFA ES 17 004 Funding Number: RFA ES 17 004 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $100,000 |
| Exposure Analysis Services for the Environmental Influences on Child Health Outcomes (ECHO) Program (Admin Supp) Apply for PA 17 308 Funding Number: PA 17 308 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Global Brain and Nervous System Disorders Research Across the Lifespan (R21) Apply for PAR 17 313 Funding Number: PAR 17 313 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $125,000 |
| Global Brain and Nervous System Disorders Research Across the Lifespan (R01) Apply for PAR 17 314 Funding Number: PAR 17 314 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Novel Assays for Screening the Effects of Chemical Toxicants on Cell Differentiation (SBIR R44) Apply for RFA ES 17 007 Funding Number: RFA ES 17 007 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Organotypic Culture Models developed from Experimental Animals for Chemical Toxicity Screening (R43) Apply for RFA ES 17 008 Funding Number: RFA ES 17 008 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Population-Based Model Organism Research for G x E Exploration in Complex Disease Outcomes (R01 Clinical Trial Not Allowed) Apply for RFA ES 17 009 Funding Number: RFA ES 17 009 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $499,999 |
| Immuno-Oncology Translational Network (IOTN): Cancer Immunotherapy Research Projects (U01) Apply for RFA CA 17 045 Funding Number: RFA CA 17 045 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $500,000 |
| Outstanding New Environmental Scientist (ONES) Award (R01 Clinical Trial Optional) Apply for RFA ES 18 001 Funding Number: RFA ES 18 001 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Environmental Health Sciences Core Centers (EHS CC) (P30 Clinical Trial Optional) Apply for RFA ES 18 003 Funding Number: RFA ES 18 003 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Transition to Independent Environmental Health Research (TIEHR) Career Transition Award (K01 Clinical Trial Required) Apply for PAR 18 261 Funding Number: PAR 18 261 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| Transition to Independent Environmental Health Research (TIEHR) Career Transition Award (K01 Clinical Trial Not Allowed) Apply for PAR 18 291 Funding Number: PAR 18 291 Agency: National Institutes of Health Category: Environment, Health Funding Amount: Case Dependent |
| The Role of the Microbiome in the Developmental Origins of Health and Disease (DOHaD) (R01 Clinical Trial Not Allowed) Apply for RFA ES 18 005 Funding Number: RFA ES 18 005 Agency: National Institutes of Health Category: Environment, Health Funding Amount: $400,000 |
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